The principal cytochrome P450 isoenzyme concerned appears being CYP2E1, with CYP1A2 and CYP3A4 as extra pathways. Close to 85% of an oral dose appears in the urine within 24 hrs of administration, most given that the glucuronide conjugate, with little quantities of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity information.Never